For research use only. Not for use in humans.
Molecular Weight(MW): 163.19
Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.Solutions of Acetylcysteine are best fresh-prepared.
Selleck's Acetylcysteine(N-acetylcysteine) has been cited by 17 publications
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|Description||Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.Solutions of Acetylcysteine are best fresh-prepared.|
N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity.  N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons.  N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells.  N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. 
|In vivo||N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. |
-  Alvirez-Freites EJ, et al. Antimicrob Agents Chemother, 2002, 46(4), 1022-1025.
-  Ferrari G, et al. J Neurosci, 1995, 15(4), 2857-2866.
-  Tsai JC, et al. J Biol Chem, 1996, 271(7), 3667-3670.
|In vitro||DMSO||33 mg/mL (202.21 mM)|
|Water||33 mg/mL (202.21 mM)|
|Ethanol||33 mg/mL (202.21 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03999021||Recruiting||Drug: NAC effervescent tablets||Retinitis Pigmentosa||Johns Hopkins University||June 24 2019||Phase 1|
|NCT03238300||Recruiting||Drug: N-Acetylcysteine|Drug: Placebo Oral Capsule||Alcohol Drinking|Control||Medical University of South Carolina|National Institute on Alcohol Abuse and Alcoholism (NIAAA)||October 16 2017||Phase 2|
|NCT03063021||Completed||Drug: N-Acetyl Cysteine (NAC)||Retinitis Pigmentosa||Johns Hopkins University||February 15 2017||Phase 1|
|NCT02583672||Recruiting||Drug: N-acetylcysteine||Gaucher Disease Type 1||University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute of Neurological Disorders and Stroke (NINDS)|Lysosomal Disease Network||September 2015||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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