Acetylcysteine(N-acetylcysteine)

For research use only. Not for use in humans.

Catalog No.S1623

17 publications

Acetylcysteine(N-acetylcysteine) Chemical Structure

Molecular Weight(MW): 163.19

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.Solutions of Acetylcysteine are best fresh-prepared.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 210 In stock
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Selleck's Acetylcysteine(N-acetylcysteine) has been cited by 17 publications

1 Customer Review

  • (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.

    Biochem Pharmacol, 2017, 146:224-232. Acetylcysteine(N-acetylcysteine) purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.Solutions of Acetylcysteine are best fresh-prepared.
Targets
ROS/ROS1 [6] TNF-α [7]
In vitro

N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. [1] N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. [2] N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. [3] N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HUVEC cells MXXGeY5kfGmxbjDhd5NigQ>? NET1fmM2KG2P MlvGOEBp NGPoOGNKdmirYnn0bY9vKG:oIFiyU|IucW6mdXPl[EBkgXSxdH;4bYNqfHliaX6gTHVXTUNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[XRiNTDtcY9tN0xiaX7jeYJifGWmIESgbJJ{KHC{aX;yJJRwKEh{T{KgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEGyJIhzeyCkeTDNWHQh[XO|YYm= M3T4SlIzQDRzMkiw
HUVEC cells M2\SeWZ2dmO2aX;uJIF{e2G7 NH;JNYo2KG2P NHvxXHM1KGh? NHeyeXFCdnSrb4jp[IFvfCCjY4Tpeol1gSCrbjDIWXZGSyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gTFJQOi2rbnT1Z4VlKEeVSDDhZ5Rqfmm2eTDheEA2KG2vb3yvUEBqdmO3YnH0[YQhPCCqcoOgdJJqd3JidH:gTFJQOiClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOTJiaILz MU[yNlg1OTJ6MB?=
rat PC12 cells NIDUcYVHfW6ldHnvckBie3OjeR?= NXHURWZXOjRiaB?= NUX6c3duUW6qaXLpeIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDpcoR2[2WmIHP5eI91d3irY3n0fUBqdiC{YYSgVGMyOiClZXzsd{BxemW2cnXheIVlKG[xcjCyOEBpenNiYYPz[ZN{\WRiYYOg[YxmfmG2aX;uJI9nKGmwdILhZ4VtdHWuYYKg[4x2fGG2aHnvcoUhdGW4ZXy= MYOxO|E2QDR3NB?=
HUVEC cells NGnidItHfW6ldHnvckBie3OjeR?= MUGy{txONDUQvF2sPO69VQ>? MVu5NI1qdg>? MV;IWXZGS3NidHjheEB4\XKnIHX4dI9{\WRid3n0bEB{\XK3bTDv[kAhWC5iZnHsZ4lx[XK3bTDhcoQhfHKnYYTl[EB4cXSqIF7BR{AzKML3Tf-8kFQhyrWP78{MPEDDvU1wIGP1dIVzdmG2YX70JIZzd21iY4XseJVz\SCjbnSgcJl{\WRiY3XscJML[3WudIXy[UB4\XKnIH3lZZN2emWmIH\vdkBJOk9{LDDHV2gh[W6mIF3ERUBt\X[nbIOu MmHTNlE3ODJ5NkO=
HUVEC cells MoHnSpVv[3Srb36gZZN{[Xl? NFvzdFAyOM7:TR?= NWPYW2g5Omh? NXHwSZNUUFWYRVPzJJdmemVicILleJJm[XSnZDD3bZRpKDFyIN88UUBPSUNiZn;yJFIhcG:3coOsJIFv\CC2aHXuJJRz\WG2ZXSge4l1cCByLkWg{txOKFCFQjCxNVgvEnC{ZYPlcpRk\SCxZjDORWMh\m:{IES4JIhwfXK|Lh?= NFXXb4ozQDV7MkG5OC=>

... Click to View More Cell Line Experimental Data

In vivo N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. [5]

Protocol

Solubility (25°C)

In vitro DMSO 33 mg/mL (202.21 mM)
Water 33 mg/mL (202.21 mM)
Ethanol 33 mg/mL (202.21 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 163.19
Formula

C5H9NO3S

CAS No. 616-91-1
Storage powder
Synonyms N/A
Smiles CC(=O)NC(CS)C(O)=O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03999021 Recruiting Drug: NAC effervescent tablets Retinitis Pigmentosa Johns Hopkins University June 24 2019 Phase 1
NCT03238300 Recruiting Drug: N-Acetylcysteine|Drug: Placebo Oral Capsule Alcohol Drinking|Control Medical University of South Carolina|National Institute on Alcohol Abuse and Alcoholism (NIAAA) October 16 2017 Phase 2
NCT03063021 Completed Drug: N-Acetyl Cysteine (NAC) Retinitis Pigmentosa Johns Hopkins University February 15 2017 Phase 1
NCT02583672 Recruiting Drug: N-acetylcysteine Gaucher Disease Type 1 University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute of Neurological Disorders and Stroke (NINDS)|Lysosomal Disease Network September 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID