CAS No. 154229-18-2

Batch: Purity:99.99
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Abiraterone Acetate Chemical Structure
Chemical Structure
Check the Abiraterone Acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
CAS Number 154229-18-2
Molecular Formula

C26H33NO2
Molecular Weight (MW) 391.55
SMILES CC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CC=C4C5=CN=CC=C5)C)C
InChIKey UVIQSJCZCSLXRZ-UBUQANBQSA-N

Biological Activity

Abiraterone Acetate is a potent steroidal inhibitor of CYP17A1 that targets 17α-hydroxylase/17,20-lyase. By selectively inhibiting CYP17A1 activity, it disrupts androgen biosynthesis and blocks testosterone production. This inhibition suppresses downstream androgen receptor pathway activation, reducing ventral prostate and seminal vesicle weights in preclinical models. Consequently, it serves as a valuable agent for studying androgen-deprivation mechanisms in castration-resistant prostate cancer.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 28 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.