CAS No. 905586-69-8
Batch:
Purity:99.05
Chemical Structure
Check the
AZ 960
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile | |
|---|---|---|
| CAS Number | 905586-69-8 | |
| Molecular Formula |
C18H16F2N6 |
|
| Molecular Weight (MW) | 354.36 | |
| SMILES | CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F | |
| InChIKey | SUNXHXDJOIXABJ-NSHDSACASA-N |
AZ 960 is a potent, ATP-competitive inhibitor of JAK2. Inhibition of the JAK/STAT signaling pathway by AZ 960 suppresses downstream phosphorylation of target proteins and downregulates anti-apoptotic Bcl-2 family members, including Bcl-2 and Mcl-1. This targeted inhibition effectively blocks cell proliferation and induces apoptosis in human T-cell lymphotropic virus type 1-infected T cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.