CAS No. 475108-18-0
| IUPAC Name | 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea | |
|---|---|---|
| CAS Number | 475108-18-0 | |
| Molecular Formula |
C22H19ClN4O5 |
|
| Molecular Weight (MW) | 454.86 | |
| SMILES | CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl | |
| InChIKey | SPMVMDHWKHCIDT-UHFFFAOYSA-N |
Tivozanib is an orally bioavailable VEGFR inhibitor targeting VEGFR1 (IC50 0.21 nM), VEGFR2 (IC50 0.16 nM), and VEGFR3 (IC50 0.24 nM). It also inhibits c-Kit (IC50 1.63 nM) and PDGFRβ (IC50 1.72 nM). By blocking receptor autophosphorylation and downstream endothelial signaling pathways, tivozanib suppresses endothelial cell proliferation and migration. Consequently, it impairs tumor angiogenesis and inhibits the growth of diverse human tumor xenografts in vivo. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(43.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
45 mg/mL
(98.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
56 mg/mL
(123.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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