CAS No. 857531-00-1

Batch: Purity:99.97
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AT7867 Chemical Structure
Chemical Structure
Check the AT7867 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
CAS Number 857531-00-1
Molecular Formula

C20H20ClN3
Molecular Weight (MW) 337.85
SMILES C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
InChIKey LZMOSYUFVYJEPY-UHFFFAOYSA-N

Biological Activity

AT7867 is a potent ATP-competitive inhibitor of Akt1, Akt2, Akt3, p70S6K, and PKA (IC50 20 nM). By blocking AKT and p70S6K signaling pathways, it suppresses downstream substrate phosphorylation, inhibits tumor cell proliferation, and induces apoptosis. In vivo, administration of AT7867 suppresses target phosphorylation and inhibits tumor growth in PTEN-deficient human glioblastoma xenograft models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (201.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Grimshaw KM, et al. Mol Cancer Ther. 2010;9(5):1100-10.

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Note: Technical data last updated: Sep 1, 2026.