CAS No. 1236699-92-5
Batch:
Purity:99.93
Chemical Structure
Check the
Pimasertib (AS-703026)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide | |
|---|---|---|
| CAS Number | 1236699-92-5 | |
| Molecular Formula |
C15H15FIN3O3 |
|
| Molecular Weight (MW) | 431.20 | |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O | |
| InChIKey | VIUAUNHCRHHYNE-JTQLQIEISA-N |
Biological Activity
Pimasertib (AS-703026) is a highly selective, ATP-noncompetitive allosteric inhibitor targeting MEK1 and MEK2. Blockade of the MAPK/ERK pathway by pimasertib suppresses cell proliferation and induces G0/G1 cell cycle arrest in multiple myeloma cells with IC50 values ranging from 0.005 to 2 μM. Additionally, pimasertib inhibits osteoclast differentiation and sensitizes multiple myeloma cells to standard anti-myeloma therapeutics.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
86 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
86 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
86 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
86 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Jump to
- Pimasertib (AS-703026) Clinical Trials
- Pimasertib (AS-703026) Solubility in DMSO
- Pimasertib (AS-703026) Stock Solution
- Pimasertib (AS-703026) Storage
- Pimasertib (AS-703026) Stability
- Pimasertib (AS-703026) Molecular Weight
- Pimasertib (AS-703026) SMILES
- Pimasertib (AS-703026) Chemical Structure (2D and 3D)
- Pimasertib (AS-703026) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.