CAS No. 935881-37-1

Batch: Purity:99.03
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AR-42 Chemical Structure
Chemical Structure
Check the AR-42 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide
CAS Number 935881-37-1
Molecular Formula

C18H20N2O3
Molecular Weight (MW) 312.36
SMILES CC(C)C(C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
InChIKey LAMIXXKAWNLXOC-INIZCTEOSA-N

Biological Activity

AR-42 is a potent, broad-spectrum histone deacetylase (HDAC) inhibitor. It promotes hyperacetylation of histones H3 and H4 as well as alpha-tubulin, suppressing HDAC activity and modulating downstream cellular signaling. AR-42 induces p21 expression, down-regulates Kit transcription, and triggers caspase-dependent apoptosis in leukemic and lymphoma cells. Furthermore, it demonstrates robust antitumor activity in vivo and prolongs survival in animal models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (201.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 63 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.