CAS No. 1002304-34-8
Batch:
Purity:99.98
Chemical Structure
Check the
AMG-208
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline | |
|---|---|---|
| CAS Number | 1002304-34-8 | |
| Molecular Formula |
C22H17N5O2 |
|
| Molecular Weight (MW) | 383.4 | |
| SMILES | COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5 | |
| InChIKey | HEAIZQNMNCHNFD-UHFFFAOYSA-N |
AMG-208 is a potent small-molecule dual inhibitor targeting c-Met and RON receptor tyrosine kinases. By suppressing c-Met receptor tyrosine kinase signaling, AMG-208 disrupts critical downstream cellular pathways involved in tumor cell survival and growth. It inhibits both ligand-dependent and ligand-independent c-Met cellular growth regulation, offering a targeted approach to impair cancer cell proliferation and tumor survival. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 4-Methylpyridine | 10 mg/mL |
| DMSO |
0.4 mg/mL
(1.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| 4-Methylpyridine | 10 mg/mL |
| DMSO |
0.33 mg/mL
(0.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| 4-Methylpyridine | 10 mg/mL |
| DMSO |
0.25 mg/mL
(0.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.