CAS No. 1034895-42-5
Batch:
Purity:99.63
Chemical Structure
Check the
Elraglusib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | |
|---|---|---|
| CAS Number | 1034895-42-5 | |
| Molecular Formula |
C22H13FN2O5 |
|
| Molecular Weight (MW) | 404.35 | |
| SMILES | CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F | |
| InChIKey | FARXPFGGGGLENU-UHFFFAOYSA-N |
Elraglusib (9-ING-41) is a small-molecule inhibitor of glycogen synthase kinase-3 (GSK-3) with potent antitumor activity. By targeting centrosomes and microtubule-bound GSK-3β, it disrupts mitotic spindle dynamics, leading to prophase cell cycle arrest and apoptosis induction. In preclinical cancer models, GSK-3 inhibition by Elraglusib suppresses pro-survival signaling pathways and attenuates tumor cell proliferation, enhancing the efficacy of chemotherapeutic agents.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.