CAS No. 5300-03-8
Batch:
Purity:99.85
Chemical Structure
Check the
9-cis-Retinoic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid | |
|---|---|---|
| CAS Number | 5300-03-8 | |
| Molecular Formula |
C20H28O2 |
|
| Molecular Weight (MW) | 300.44 | |
| InChIKey | SHGAZHPCJJPHSC-ZVCIMWCZSA-N |
Biological Activity
9-cis-Retinoic acid is an active metabolite of vitamin A that acts as a high-affinity endogenous ligand for retinoid X receptors (RXRs) and retinoic acid receptors (RARs). Through modulation of RXR/RAR-mediated transcriptional pathways, it regulates downstream gene expression and inhibits adipogenesis by activating RXR while simultaneously reducing intracellular RXRα and PPARγ protein levels in an RXR activation-independent manner. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.