CAS No. 90-45-9

Batch: Purity:99.87
Check CoA
9-Aminoacridine Chemical Structure
Chemical Structure
Check the 9-Aminoacridine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name acridin-9-amine
CAS Number 90-45-9
Molecular Formula

C13H10N2
Molecular Weight (MW) 194.23
SMILES C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N
InChIKey XJGFWWJLMVZSIG-UHFFFAOYSA-N

Biological Activity

9-Aminoacridine (Aminacrine) is a fluorescent acridine derivative that acts as a DNA intercalating agent and dual modulator of p53 and NF-kB signaling pathways. It induces p53-dependent transcriptional activation while simultaneously inhibiting NF-kB-mediated gene expression. These downstream effects lead to suppression of pro-survival signaling, cell cycle arrest, and the induction of apoptosis in various cancer cell lines. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (195.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 38 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gurova KV, et al. Proc Natl Acad Sci U S A. 2005;102(48):17448-53.

Jump to

Note: Technical data last updated: Sep 1, 2026.