CAS No. 57420-46-9

Batch: Purity:99.86
Check CoA
8-O-acetyl shanzhiside methyl ester Chemical Structure
Chemical Structure
Check the 8-O-acetyl shanzhiside methyl ester product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (1S,4aS,5R,7S,7aS)-7-acetyloxy-5-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylate
CAS Number 57420-46-9
Molecular Formula

C19H28O12
Molecular Weight (MW) 448.42
SMILES CC(=O)OC1(CC(C2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O)C
InChIKey ARFRZOLTIRQFCI-NGQYDJQZSA-N

Ordering Information

Biological Activity

8-O-acetyl shanzhiside methyl ester is a natural iridoid glycoside isolated from Lamiophlomis rotata Kudo that acts as an NF-kB inhibitor. By suppressing NF-kB-mediated inflammatory signaling, it reduces neuroinflammatory responses and modulates cell survival. Additionally, it promotes angiogenesis in ischemic tissue, which enhances microvascular remodeling and leads to improved functional outcomes after stroke.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.