CAS No. 35873-49-5

Batch: Purity:99.91
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8-Cyclopentyl-1,3-dimethylxanthine Chemical Structure
Chemical Structure
Check the 8-Cyclopentyl-1,3-dimethylxanthine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 35873-49-5
Molecular Formula

C12H16N4O2
Molecular Weight (MW) 248.28

Biological Activity

8-Cyclopentyl-1,3-dimethylxanthine is a selective adenosine A1 receptor antagonist that targets adenosine A1 and A2 receptors with marked selectivity for the A1 subtype. By blocking adenosine A1 receptors, it inhibits G protein-coupled receptor signaling, leading to modulated adenylate cyclase activity and altered cyclic AMP (cAMP) levels. This inhibition influences neurotransmitter release, renal function, and cardiac electrophysiology. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (100.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] BMJ. 1990;300(6726):698-698.

[2] Fredholm BB, et al. Pharmacol Rev. 2001;53(4):527-52.

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Note: Technical data last updated: Sep 1, 2026.