CAS No. 10299-44-2
Batch:
Purity:99.76
Chemical Structure
Check the
8-Azaadenosine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4S,5R)-2-(7-aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol | |
|---|---|---|
| CAS Number | 10299-44-2 | |
| Molecular Formula |
C9H12N6O4 |
|
| Molecular Weight (MW) | 268.23 | |
| InChIKey | OAUKGFJQZRGECT-UUOKFMHZSA-N |
8-Azaadenosine is a small-molecule nucleoside analog and potent inhibitor of adenosine deaminase acting on RNA 1 (ADAR1) and adenosine-to-inosine (A-to-I) RNA editing activity. By selectively blocking ADAR1-dependent RNA editing pathways, 8-azaadenosine disrupts downstream oncogenic gene expression and cellular phenotypes. Consequently, treatment with this agent significantly suppresses cancer cell proliferation, three-dimensional spheroid growth, invasion, and cell migration. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(201.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.