CAS No. 1429617-90-2

Batch: Purity:99.18
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7rh Chemical Structure
Chemical Structure
Check the 7rh product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
CAS Number 1429617-90-2
Molecular Formula

C30H29F3N6O
Molecular Weight (MW) 546.59
InChIKey DDLPXZXBWGJRGK-UHFFFAOYSA-N

Ordering Information

Biological Activity

7rh is a potent kinase inhibitor of discoidin domain receptor 1 (DDR1) that also inhibits discoidin domain receptor 2 (DDR2) with reduced potency. By suppressing DDR1 enzymatic activity and receptor phosphorylation, 7rh downregulates downstream signaling pathways to inhibit cancer cell proliferation, invasion, and adhesion. Additionally, 7rh exhibits marked antitumor effects in nasopharyngeal carcinoma cells, suppressing cell growth and tumorigenicity.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (182.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.