CAS No. 916440-85-2
Batch:
Purity:99.28
Chemical Structure
Check the
7BIO
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol | |
|---|---|---|
| CAS Number | 916440-85-2 | |
| Molecular Formula |
C16H10BrN3O2 |
|
| Molecular Weight (MW) | 356.17 | |
| SMILES | O\N=C1\C(NC2=CC=CC=C12)=C/3C(=O)NC4=C(Br)C=CC=C34 | |
| InChIKey | HYMACPDEJIEMST-UHFFFAOYSA-N |
7BIO is an indirubin derivative functioning as a dual inhibitor of cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). Through modulation of kinase pathways, 7BIO mitigates amyloid-β oligomer-induced tau hyperphosphorylation, neuroinflammation, and synaptic toxicity while attenuating astrocyte and microglial activation. Additionally, 7BIO triggers mitochondrial membrane collapse and caspase-independent necrotic cell death in multiple cell line models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.