CAS No. 566-27-8
Batch:
Purity:99.50
Chemical Structure
Check the
7β-Hydroxycholesterol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 566-27-8 | |
|---|---|---|
| Molecular Formula |
C27H46O2 |
|
| Molecular Weight (MW) | 402.65 |
7β-Hydroxycholesterol is a bioactive oxysterol derived from the oxidation of cholesterol. It induces endothelial cell apoptosis, oxidative stress, and IL-1β secretion, promoting organelle dysfunction and inflammatory signaling. Furthermore, 7β-hydroxycholesterol upregulates key cell adhesion molecules, including ICAM-1, VCAM-1, and E-selectin, thereby enhancing leukocyte adhesion and contributing to the early development of vascular pathology and atherosclerosis.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(201.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 27 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.