CAS No. 2942-42-9
Batch:
Purity:99.15
Chemical Structure
Check the
7-Nitroindazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-nitro-1H-indazole | |
|---|---|---|
| CAS Number | 2942-42-9 | |
| Molecular Formula |
C7H5N3O2 |
|
| Molecular Weight (MW) | 163.13 | |
| SMILES | C1=CC2=C(C(=C1)[N+](=O)[O-])NN=C2 | |
| InChIKey | PQCAUHUKTBHUSA-UHFFFAOYSA-N |
Biological Activity
7-Nitroindazole is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) that demonstrates 10-fold selectivity for nNOS over endothelial nitric oxide synthase (eNOS). By targeted inhibition of nNOS, the compound effectively blocks nitric oxide production in central neuronal pathways. This inhibition leads to downstream pharmacological phenotypes, including marked antinociceptive and neuroprotective activities in various animal models without significantly altering arterial blood pressure. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(196.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.