CAS No. 2445-83-2
Batch:
Purity:99.88
Chemical Structure
Check the
7-Methylcoumarin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2445-83-2 | |
|---|---|---|
| Molecular Formula |
C10H8O2 |
|
| Molecular Weight (MW) | 160.17 | |
| SMILES | CC1=CC2=C(C=C1)C=CC(=O)O2 |
7-Methylcoumarin is a coumarin derivative that acts as a mechanism-based inhibitor of human cytochrome P2A6 (CYP2A6). It exhibits potent hepatoprotective and antioxidant activities in CCl4-induced liver injury models. Treatment with 7-methylcoumarin significantly attenuates hepatic damage by reducing serum ALT, AST, and total bilirubin levels, inhibiting lipid peroxidation, and restoring endogenous antioxidant enzymes, including superoxide dismutase and catalase. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.