CAS No. 19037-69-5

Batch: Purity:99.72
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7-Hydroxy-4-methyl-8-nitrocoumarin Chemical Structure
Chemical Structure
Check the 7-Hydroxy-4-methyl-8-nitrocoumarin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-hydroxy-4-methyl-8-nitrochromen-2-one
CAS Number 19037-69-5
Molecular Formula

C10H7NO5
Molecular Weight (MW) 221.17
SMILES CC1=CC(=O)OC2=C1C=CC(=C2[N+](=O)[O-])O
InChIKey BGUBUSIGKOWDPO-UHFFFAOYSA-N

Ordering Information

Biological Activity

7-Hydroxy-4-methyl-8-nitrocoumarin is a nitro-substituted derivative of 7-hydroxy-4-methylcoumarin (4-methylumbelliferone), belonging to the coumarin family of bioactive compounds. Coumarin derivatives, such as 4-methylumbelliferone, function as inhibitors of hyaluronan synthesis by downregulating hyaluronan synthase expression and depleting cellular UDP-glucuronic acid pools. Suppression of hyaluronan production alters the extracellular matrix microenvironment, leading to attenuated cell proliferation, reduced cell migration, and inhibition of tumor growth in various preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.