CAS No. 2196-14-7
Batch:
Purity:95.13
Chemical Structure
Check the
7,4'-Dihydroxyflavone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one | |
|---|---|---|
| CAS Number | 2196-14-7 | |
| Molecular Formula |
C15H10O4 |
|
| Molecular Weight (MW) | 254.24 | |
| InChIKey | LCAWNFIFMLXZPQ-UHFFFAOYSA-N |
7,4'-Dihydroxyflavone is a natural flavonoid isolated from Glycyrrhiza uralensis that acts as an inhibitor of eotaxin/CCL11 expression and carbonyl reductase 1 (CBR1). It suppresses eotaxin production in human lung fibroblasts and mitigates dexamethasone-induced eotaxin upregulation. Additionally, 7,4'-dihydroxyflavone attenuates PMA-stimulated MUC5AC gene expression and mucin production in human airway epithelial cells, highlighting its potential anti-inflammatory and mucoregulatory activities. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.