CAS No. 57-97-6

Batch: Purity:99.50
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DMBA chemical (7,12-Dimethylbenz[a]anthracene) Chemical Structure
Chemical Structure
Check the DMBA chemical (7,12-Dimethylbenz[a]anthracene) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7,12-dimethylbenzo[a]anthracene
CAS Number 57-97-6
Molecular Formula

C20H16
Molecular Weight (MW) 256.34
SMILES CC1=C2C=CC3=CC=CC=C3C2=C(C)C4=CC=CC=C14
InChIKey ARSRBNBHOADGJU-UHFFFAOYSA-N

Biological Activity

7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon that functions as an immunosuppressive agent and potent organ-specific procarcinogen metabolized by cytochrome Penzymes such as CYP1B Metabolic activation of DMBA generates reactive diol-epoxide intermediates that form DNA adducts, leading to genotoxicity, bone marrow suppression, and preleukemic cell formation. Additionally, CYP1B1-dependent bioactivation mediates spleen cell immunotoxicity and suppresses humoral immune responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (198.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Heidel SM, et al. Cancer Res. 2000;60(13):3454-60.

[2] Gao J, et al. Toxicol Sci. 2005;86(1):68-74.

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Note: Technical data last updated: Sep 1, 2026.