CAS No. 2702965-27-1
Batch:
Purity:99.79
Chemical Structure
Check the
6K465
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3-chloro-2-fluorophenyl)-[4-[[4-(4-ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]piperidin-1-yl]methanone | |
|---|---|---|
| CAS Number | 2702965-27-1 | |
| Molecular Formula |
C26H33ClFN9O |
|
| Molecular Weight (MW) | 542.05 | |
| InChIKey | NKCRCYYIMDOKFP-UHFFFAOYSA-N |
6K465 is a pyrimidine-based Aurora A inhibitor that effectively reduces the levels of c-MYC and N-MYC oncoproteins. Targeted inhibition of Aurora A disrupts kinase interactions with MYC, leading to MYC protein degradation and suppression of downstream oncogenic signaling pathways. This reduction in MYC drivers blocks tumor cell proliferation and exhibits compelling antitumor efficacy across preclinical disease models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(184.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(184.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.