CAS No. 72401-54-8

Batch: Purity:99.51
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6-Methoxydihydrosanguinarine Chemical Structure
Chemical Structure
Check the 6-Methoxydihydrosanguinarine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 23-methoxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21)-octaene
CAS Number 72401-54-8
Molecular Formula

C21H17NO5
Molecular Weight (MW) 363.36
SMILES CN1C(C2=CC3=C(C=C2C4=C1C5=CC6=C(C=C5C=C4)OCO6)OCO3)OC
InChIKey MHPDDMNAUJQRSW-UHFFFAOYSA-N

Ordering Information

Biological Activity

6-Methoxydihydrosanguinarine is a natural benzophenanthridine alkaloid isolated from Macleaya cordata that exhibits potent cytotoxic and antiproliferative activity against human cancer cells, including breast carcinoma MCF-7 and central nervous system cancer SF-268 cell lines. By disrupting cellular survival signaling, this compound suppresses cancer cell growth and promotes apoptotic cell death, serving as a promising natural lead compound in antineoplastic research.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1.5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.