CAS No. 20035-41-0

Batch: Purity:99.90
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6-Bromo-2-hydroxy-3-methoxybenzaldehyde Chemical Structure
Chemical Structure
Check the 6-Bromo-2-hydroxy-3-methoxybenzaldehyde product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-bromo-2-hydroxy-3-methoxybenzaldehyde
CAS Number 20035-41-0
Molecular Formula

C8H7BrO3
Molecular Weight (MW) 231.04
SMILES COC1=C(C(=C(C=C1)Br)C=O)O
InChIKey JUPJZUTYDWXZAQ-UHFFFAOYSA-N

Biological Activity

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that acts as a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). Targeting IRE1α selectively impairs its endoribonuclease activity and prevents downstream XBP1 mRNA splicing within the unfolded protein response (UPR) pathway. This inhibition attenuates adaptive endoplasmic reticulum (ER) stress signaling, ultimately suppressing cell survival and inducing apoptosis in stressed cell populations. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 46 mg/mL (199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] EMBO J. 2012;31(15):3231-3233.

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Note: Technical data last updated: Sep 1, 2026.