CAS No. 168649-23-8

Batch: Purity:99.79
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5-Ph-IAA Chemical Structure
Chemical Structure
Check the 5-Ph-IAA product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(5-phenyl-1H-indol-3-yl)acetic acid
CAS Number 168649-23-8
Molecular Formula

C16H13NO2
Molecular Weight (MW) 251.28
InChIKey ACCCWYHBDGKDKN-UHFFFAOYSA-N

Biological Activity

5-Ph-IAA is a synthetic auxin derivative and bumped-IAA analogue that functions as a chemical inducer of proximity in the auxin-inducible degron 2 (AID2) system by selectively binding OsTIR1(F74G). Engagement of 5-Ph-IAA with the mutant OsTIR1(F74G) receptor recruits target proteins fused with a mini-auxin-inducible degron tag to the SCF ubiquitin ligase complex, facilitating rapid ubiquitin-mediated proteasomal degradation. This precise, inducible depletion enables functional characterization of target proteins in living cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nat Commun. 2020;11(1).

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Note: Technical data last updated: Sep 1, 2026.