CAS No. 134-35-0
Batch:
Purity:98.946
Chemical Structure
Check the
5-Methyltetrahydrofolic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 134-35-0 | |
|---|---|---|
| Molecular Formula |
C20H25N7O6 |
|
| Molecular Weight (MW) | 459.46 |
5-Methyltetrahydrofolate (5-MTHF) is the biologically active form of folic acid and an essential micronutrient involved in one-carbon metabolism. It enhances endothelial function by stimulating endothelin-1 (ET-1) production in low-density lipoprotein (LDL)-treated endothelial cells, mediated by specific 5-MTHF-LDL interactions and antioxidant properties. Through these pathways, 5-MTHF helps reduce lipid peroxidation and regulate vascular tone to support cardiovascular health. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 5-Methyltetrahydrofolic acid Solubility in DMSO
- 5-Methyltetrahydrofolic acid Stock Solution
- 5-Methyltetrahydrofolic acid Storage
- 5-Methyltetrahydrofolic acid Stability
- 5-Methyltetrahydrofolic acid Molecular Weight
- 5-Methyltetrahydrofolic acid Chemical Structure (2D and 3D)
- 5-Methyltetrahydrofolic acid SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.