CAS No. 10075-50-0
Batch:
Purity:99.97
Chemical Structure
Check the
5-Bromoindole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-bromo-1H-indole | |
|---|---|---|
| CAS Number | 10075-50-0 | |
| Molecular Formula |
C8H6BrN |
|
| Molecular Weight (MW) | 196.04 | |
| SMILES | C1=CC2=C(C=CN2)C=C1Br | |
| InChIKey | VXWVFZFZYXOBTA-UHFFFAOYSA-N |
5-Bromoindole is a halogenated indole derivative that acts as a synthetic building block and a potential inhibitor of glycogen synthase kinase 3 (GSK-3). Modulation of GSK-3 activity influences downstream signaling cascades, including the Wnt/β-catenin pathway and tau protein phosphorylation, affecting processes such as cell proliferation, neural development, and glycogen metabolism. As a chemical intermediate, it serves as a core scaffold for synthesizing complex bioactive heterocyclic compounds and targeted kinase inhibitors.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
39 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.