CAS No. 61-19-8

Batch: Purity:99.03
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5'-Adenylic acid Chemical Structure
Chemical Structure
Check the 5'-Adenylic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 61-19-8
Molecular Formula

C10H14N5O7P
Molecular Weight (MW) 347.22
SMILES C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N

Ordering Information

Biological Activity

5'-Adenylic acid (AMP) is an endogenous purine nucleotide and a natural activator of AMP-activated protein kinase (AMPK). Binding of AMP to the regulatory gamma subunit of AMPK allosterically activates the kinase and promotes phosphorylation by upstream kinases. This activation regulates downstream metabolic signaling, promoting energy-generating catabolic pathways while inhibiting energy-consuming anabolic processes to maintain cellular energy homeostasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34.9 mg/mL (100.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.