CAS No. 21392-57-4
Batch:
Purity:99.78
Chemical Structure
Check the
5,7-Dimethoxyflavone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,7-dimethoxy-2-phenylchromen-4-one | |
|---|---|---|
| CAS Number | 21392-57-4 | |
| Molecular Formula |
C17H14O4 |
|
| Molecular Weight (MW) | 282.29 | |
| SMILES | COC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)OC | |
| InChIKey | JRFZSUMZAUHNSL-UHFFFAOYSA-N |
5,7-Dimethoxyflavone (5,7-DMF) is a natural flavonoid derivative that acts as an inhibitor of cytochrome P450 3A (CYP3A) enzymes and breast cancer resistance protein (BCRP/ABCG2). It decreases the hepatic expression of CYP3A11 and CYP3A25 and suppresses ABCG2-mediated efflux transport. As a major bioactive component of Kaempferia parviflora, it exerts anti-inflammatory, antineoplastic, and anti-obesity effects by attenuating pro-inflammatory cellular signaling pathways.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(354.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.