CAS No. 31721-94-5

Batch: Purity:99.98
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5,7-Dihydroxychromone Chemical Structure
Chemical Structure
Check the 5,7-Dihydroxychromone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 31721-94-5
Molecular Formula

C9H6O4
Molecular Weight (MW) 178.14
SMILES OC1=CC(=C2C(=O)C=COC2=C1)O

Ordering Information

Biological Activity

5,7-Dihydroxychromone (DHC) is a plant-derived antioxidant compound that acts as a potent activator of Nrf2/ARE signaling, as well as PPAR and LXR pathways. Activation of Nrf2/ARE signaling promotes the nuclear translocation of Nrf2, leading to the upregulation of downstream antioxidant genes, attenuated reactive oxygen species generation, and reduced neuronal apoptosis. Concurrently, upregulation of PPARγ and LXRα expression induces adipocyte differentiation, supporting blood glucose regulation and exhibiting anti-diabetic activity. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 9 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.