CAS No. 910462-43-0

Batch: Purity:99.84
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Domatinostat (4SC-202) Chemical Structure
Chemical Structure
Check the Domatinostat (4SC-202) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-N-(2-aminophenyl)-3-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpyrrol-3-yl]prop-2-enamide
CAS Number 910462-43-0
Molecular Formula

C23H21N5O3S
Molecular Weight (MW) 447.51
SMILES CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)C=CC(=O)NC4=CC=CC=C4N
InChIKey PRXXYMVLYKJITB-IZZDOVSWSA-N

Ordering Information

Biological Activity

Domatinostat (4SC-202) is an orally active, selective class I histone deacetylase (HDAC) inhibitor targeting HDAC1, HDAC2, and HDAC3, while also exhibiting inhibitory activity against lysine-specific demethylase 1 (LSD1). By suppressing class I HDACs, Domatinostat promotes hyperacetylation of core histones, alters gene expression profiles, and induces cell cycle arrest and apoptosis in tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.