CAS No. 55399-93-4

Batch: Purity:98.33
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(4S)-4-Hydroxy-L-isoleucine Chemical Structure
Chemical Structure
Check the (4S)-4-Hydroxy-L-isoleucine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 55399-93-4
Molecular Formula

C6H13NO3
Molecular Weight (MW) 147.17
SMILES CC(C(C)O)C(C(=O)O)N

Ordering Information

Biological Activity

(4S)-4-Hydroxy-L-isoleucine is a plant metabolite and natural insulinotropic amino acid derivative. It stimulates glucose-dependent insulin secretion directly in pancreatic beta cells without altering basal insulin levels. Furthermore, it enhances glucose metabolism and improves insulin resistance by promoting insulin receptor substrate (IRS) signaling and downstream AKT/mTOR pathway activation in target metabolic tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 29 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.