CAS No. 20426-12-4
Batch:
Purity:99.87
Chemical Structure
Check the
4-Hydroxychalcone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one | |
|---|---|---|
| CAS Number | 20426-12-4 | |
| Molecular Formula |
C15H12O2 |
|
| Molecular Weight (MW) | 224.25 | |
| SMILES | C1=CC=C(C=C1)C(=O)C=CC2=CC=C(C=C2)O | |
| InChIKey | PWWCDTYUYPOAIU-DHZHZOJOSA-N |
4-Hydroxychalcone is a chalcone metabolite that acts as an inhibitor of TNF-induced NF-kB pathway activation and an activator of BMP signaling. By suppressing NF-kB signaling, it downregulates pro-inflammatory gene expression and cellular inflammatory responses, while activation of the BMP signaling pathway drives downstream transcriptional events promoting osteogenic differentiation and cell lineage specification.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
44 mg/mL
(196.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.