CAS No. 4319-68-0

Batch: Purity:99
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4′-Deoxyphlorizin Chemical Structure
Chemical Structure
Check the 4′-Deoxyphlorizin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(4-hydroxyphenyl)-1-[2-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]propan-1-one
CAS Number 4319-68-0
Molecular Formula

C21H24O9
Molecular Weight (MW) 420.41
SMILES C1=CC(=C(C(=C1)OC2C(C(C(C(O2)CO)O)O)O)C(=O)CCC3=CC=C(C=C3)O)O
InChIKey KOTXSQPZNZHNFC-UHFFFAOYSA-N

Biological Activity

4′-Deoxyphlorizin is a phenolic glucoside derivative that acts as an inhibitor of the glucose transport system. By interfering with transmembrane glucose transport mechanisms and sodium-coupled glucose cotransporters, it effectively blocks cellular glucose uptake across epithelial cell membranes. This targeted inhibition subsequently suppresses downstream intracellular glucose metabolism and disrupts signaling pathways required for cellular energy homeostasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Wright EM, et al. Physiol Rev. 2011;91(2):733-94.

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Note: Technical data last updated: Sep 1, 2026.