CAS No. 5106-98-9

Batch: Purity:99.81
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4-Chlorosalicylic acid Chemical Structure
Chemical Structure
Check the 4-Chlorosalicylic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-chloro-2-hydroxybenzoic acid
CAS Number 5106-98-9
Molecular Formula

C7H5ClO3
Molecular Weight (MW) 172.57
SMILES C1=CC(=C(C=C1Cl)O)C(=O)O
InChIKey LWXFCZXRFBUOOR-UHFFFAOYSA-N

Biological Activity

4-Chlorosalicylic acid is a salicylic acid derivative that acts as an inhibitor of tyrosinase, targeting both monophenolase and diphenolase activities. By blocking these catalytic functions, it suppresses enzymatic browning and melanin biosynthesis pathways, leading to altered cellular pigmentation. Additionally, 4-chlorosalicylic acid exhibits antimicrobial properties against bacterial pathogens such as Escherichia coli, disrupting cell membrane integrity and inhibiting microbial growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34 mg/mL (197.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 34 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chang TS. Int J Mol Sci. 2009;10(6):2440-2475.

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Note: Technical data last updated: Sep 1, 2026.