CAS No. 7424-00-2

Batch: Purity:99.99
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4-Chloro-DL-phenylalanine Chemical Structure
Chemical Structure
Check the 4-Chloro-DL-phenylalanine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 7424-00-2
Molecular Formula

C9H10ClNO2
Molecular Weight (MW) 199.63
SMILES C1=CC(=CC=C1CC(C(=O)O)N)Cl

Ordering Information

Biological Activity

4-Chloro-DL-phenylalanine (Fenclonine, PCPA) is a selective and irreversible inhibitor of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. By inhibiting tryptophan hydroxylase, it suppresses central and peripheral serotonin production, leading to depletion of endogenous serotonin levels. This reduction in serotonin signaling impacts downstream serotonergic neurotransmission and associated physiological functions, making it a key tool in neuropharmacological research on mood, sleep, and behavioral regulation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 3.75 mg/mL
DMSO 2 mg/mL (10.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.