CAS No. 14348-38-0

Batch: Purity:99.22
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4-Bromo-3-hydroxybenzoic acid Chemical Structure
Chemical Structure
Check the 4-Bromo-3-hydroxybenzoic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-bromo-3-hydroxybenzoic acid
CAS Number 14348-38-0
Molecular Formula

C7H5BrO3
Molecular Weight (MW) 217.02
SMILES C1=CC(=C(C=C1C(=O)O)O)Br
InChIKey PAJSESFUWIYFNF-UHFFFAOYSA-N

Biological Activity

4-Bromo-3-hydroxybenzoic acid acts as a potent inhibitor of histidine decarboxylase, the primary enzyme responsible for catalyzing the decarboxylation of L-histidine to histamine. By suppressing histidine decarboxylase activity, this compound inhibits endogenous histamine formation and depletes tissue histamine levels in mammals. Consequently, downstream histamine receptor-mediated signaling pathways and associated inflammatory responses are diminished. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (198.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Komori H, et al. J Biol Chem. 2012;287(36):30688-700.

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Note: Technical data last updated: Sep 1, 2026.