CAS No. 5334-30-5
Batch:
Purity:99.05
![4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Chemical Structure](https://file.selleckchem.com/downloads/struct/e2980-4-AMino-1-phenylpyrazolo-3-4-d-pyriMidine-chemical-structure.png)
Chemical Structure
Check the
4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 5334-30-5 | |
| Molecular Formula |
C11H9N5 |
|
| Molecular Weight (MW) | 211.22 | |
| InChIKey | KKDPIZPUTYIBFX-UHFFFAOYSA-N |
4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine (PP3) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with an IC50 of 2.7 μM. It functions as an inactive structural analogue and negative control for the Src family kinase inhibitor PP2. By lacking potent Src inhibitory activity, PP3 serves as a valuable control to distinguish specific Src-mediated phosphorylation events and downstream cellular signaling phenotypes from non-specific chemical effects in biological studies.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(198.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Solubility in DMSO
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Stock Solution
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Storage
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Stability
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Molecular Weight
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine Chemical Structure (2D and 3D)
- 4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.