CAS No. 5128-44-9

Batch: Purity:99.21
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4',7-Dimethoxy-5-Hydroxyflavone Chemical Structure
Chemical Structure
Check the 4',7-Dimethoxy-5-Hydroxyflavone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
CAS Number 5128-44-9
Molecular Formula

C17H14O5
Molecular Weight (MW) 298.29
SMILES COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O
InChIKey LZERJKGWTQYMBB-UHFFFAOYSA-N

Ordering Information

Biological Activity

4',7-Dimethoxy-5-hydroxyflavone is a dietary flavonoid derivative that acts as a dual inhibitor of α-glucosidase and α-amylase. By attenuating the activity of these primary carbohydrate-hydrolyzing enzymes, the compound limits enzymatic glucose cleavage. Additionally, 4',7-dimethoxy-5-hydroxyflavone enhances cellular glucose uptake, promoting 2-NBDG internalization in L6 skeletal muscle cells to support metabolic pathway regulation and cellular glucose homeostasis.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (23.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.