CAS No. 72-55-9
Batch:
Purity:99.96
Chemical Structure
Check the
4,4'-DDE
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 72-55-9 | |
|---|---|---|
| Molecular Formula |
C14H8Cl4 |
|
| Molecular Weight (MW) | 318.03 | |
| SMILES | C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl |
4,4'-DDE is a persistent organochlorine pesticide metabolite that functions as a potent antagonist of the androgen receptor. By selectively binding to the androgen receptor, 4,4'-DDE blocks androgenic hormone interactions and inhibits transcriptional activation of androgen-responsive genes. This inhibition disrupts downstream androgen receptor signaling pathways, impairing cellular proliferation and physiological processes dependent on active androgen receptor activation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(198.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.