CAS No. 1486-70-0

Batch: Purity:98.40
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3-O-Methylquercetin Chemical Structure
Chemical Structure
Check the 3-O-Methylquercetin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one
CAS Number 1486-70-0
Molecular Formula

C16H12O7
Molecular Weight (MW) 316.26
InChIKey WEPBGSIAWZTEJR-UHFFFAOYSA-N

Biological Activity

3-O-Methylquercetin is a natural flavone isolated from Rhamnus nakaharai that acts as an inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDE) and beta-secretase (BACE1). By inhibiting PDE enzymes, it elevates intracellular cAMP and cGMP levels, modulating cyclic nucleotide signaling pathways to induce vascular smooth muscle relaxation and anti-inflammatory responses. Furthermore, BACE1 inhibition attenuates amyloid-beta precursor processing, demonstrating neuroprotective and antiviral biological activities. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] VR. 1990;[1990] VR:859-880.

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Note: Technical data last updated: Sep 1, 2026.