CAS No. 1076-22-8
Batch:
Purity:99.98
Chemical Structure
Check the
3-Methylxanthine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-methyl-7H-purine-2,6-dione | |
|---|---|---|
| CAS Number | 1076-22-8 | |
| Molecular Formula |
C6H6N4O2 |
|
| Molecular Weight (MW) | 166.14 | |
| SMILES | CN1C(=O)NC(=O)C2=C1N=C[NH]2 | |
| InChIKey | GMSNIKWWOQHZGF-UHFFFAOYSA-N |
Biological Activity
3-Methylxanthine (3-MX) is a 3-alkylxanthine derivative and cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) inhibitor with an IC50 ofon guinea-pig isolated trachealis muscle. By inhibiting PDE activity, it prevents the degradation of cyclic nucleotides, thereby elevating intracellular cGMP levels. This accumulation leads to smooth muscle relaxation and bronchodilation, modulating cyclic nucleotide-dependent signaling pathways involved in airway tone regulation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(48.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.