CAS No. 7423-55-4

Batch: Purity:99.55
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3-Maleimidopropionic acid Chemical Structure
Chemical Structure
Check the 3-Maleimidopropionic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 7423-55-4
Molecular Formula

C7H7NO4
Molecular Weight (MW) 169.13
SMILES C1=CC(=O)N(C1=O)CCC(=O)O

Biological Activity

3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker and bioconjugation reagent used in chemical biology. Incorporating maleimide functionality, it enables covalent conjugation to thiol-containing motifs, facilitating the synthesis of proteolysis targeting chimeras (PROTACs). These bifunctional degraders recruit E3 ubiquitin ligase complexes to target proteins, promoting polyubiquitination and subsequent proteasomal degradation to modulate downstream cellular pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34 mg/mL (201.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 34 mg/mL
Ethanol 34 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Fontaine SD, et al. Bioconjug Chem. 2015;26(1):145-52.

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Note: Technical data last updated: Sep 1, 2026.