CAS No. 830-96-6

Batch: Purity:99.94
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3-Indolepropionic acid Chemical Structure
Chemical Structure
Check the 3-Indolepropionic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(1H-indol-3-yl)propanoic acid
CAS Number 830-96-6
Molecular Formula

C11H11NO2
Molecular Weight (MW) 189.21
SMILES C1=CC=C2C(=C1)C(=CN2)CCC(=O)O
InChIKey GOLXRNDWAUTYKT-UHFFFAOYSA-N

Ordering Information

Biological Activity

3-Indolepropionic acid is a gut microbial metabolite that acts as a neuroprotective antioxidant and an agonist of the pregnane X receptor (PXR). By scavenging free radicals and activating PXR-mediated signaling, 3-Indolepropionic acid suppresses mucosal inflammation and maintains intestinal epithelial barrier integrity. In neuronal models, it attenuates amyloid-beta-induced oxidative stress and prevents neurotoxicity. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 37 mg/mL (195.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.