CAS No. 300-85-6
Batch:
Purity:99.45
Chemical Structure
Check the
3-Hydroxybutyric acid (BHB acid)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-hydroxybutanoic acid | |
|---|---|---|
| CAS Number | 300-85-6 | |
| Molecular Formula |
C4H8O3
|
|
| Molecular Weight (MW) | 104.10 | |
| InChIKey | WHBMMWSBFZVSSR-UHFFFAOYSA-N |
3-Hydroxybutyric acid (BHB) is a key endogenous ketone body metabolite that acts as an endogenous histone deacetylase (HDAC) inhibitor. It functions as a regulatory signaling molecule that suppresses oxidative stress through HDAC inhibition and selectively blocks activation of the NLRP3 inflammasome, downstream inhibiting caspase-1 cleavage and IL-1β secretion to modulate cellular stress responses and inflammatory pathways. [1][2]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
21 mg/mL
(201.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 21 mg/mL |
| Ethanol | 21 mg/mL |
| DMSO |
100 mg/mL
(960.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.