CAS No. 13887-98-4

Batch: Purity:99.97
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3,6,9-Trioxaundecanedioic Acid Chemical Structure
Chemical Structure
Check the 3,6,9-Trioxaundecanedioic Acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 13887-98-4
Molecular Formula

C8H14O7
Molecular Weight (MW) 222.19
SMILES C(COCC(=O)O)OCCOCC(=O)O

Biological Activity

3,6,9-Trioxaundecanedioic acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). By tethering a target protein-binding moiety to an E3 ubiquitin ligase ligand, this functionalized linker facilitates the assembly of a stable ternary complex. This interaction promotes localized polyubiquitination and subsequent proteasomal degradation of target proteins within intracellular signaling pathways.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (198.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 44 mg/mL
Ethanol 44 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.