CAS No. 624-95-3
Batch:
Purity:100.00
Chemical Structure
Check the
3,3-Dimethyl-1-butanol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 624-95-3 | |
|---|---|---|
| Molecular Formula |
C6H14O |
|
| Molecular Weight (MW) | 102.17 |
3,3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of gut microbial trimethylamine (TMA) lyase, preventing the enzymatic generation of TMA and its subsequent conversion to trimethylamine N-oxide (TMAO). By suppressing TMA and TMAO levels, this compound negatively regulates downstream p65 NF-κB and TGF-β1/Smad3 signaling pathways. Consequently, it attenuates vascular inflammation, inhibits macrophage foam cell formation, and protects against diet-induced atherosclerosis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(195.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 20 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.