CAS No. 156-28-5

Batch: Purity:98
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2-Phenylethylamine hydrochloride Chemical Structure
Chemical Structure
Check the 2-Phenylethylamine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 156-28-5
Molecular Formula

C8H11N.HCl
Molecular Weight (MW) 157.64
SMILES C1=CC=C(C=C1)CCN.Cl

Biological Activity

2-Phenylethylamine hydrochloride is an endogenous trace amine that functions as a potent agonist of trace amine-associated receptor 1 (TAAR1). Activation of TAAR1 stimulates adenylyl cyclase activity, increasing intracellular cAMP levels to modulate monoaminergic neurotransmission in the central nervous system. Downstream, this receptor activation regulates dopamine and serotonin release and transport, thereby influencing neuronal excitability, mood, and locomotor signaling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 31 mg/mL (196.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Bunzow JR, et al. Mol Pharmacol. 2001;60(6):1181-8.

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Note: Technical data last updated: Sep 1, 2026.