CAS No. 129499-78-1
Batch:
Purity:99.71
Chemical Structure
Check the
2-O-α-D-Glucopyranosyl-L-ascorbic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 129499-78-1 | |
|---|---|---|
| Molecular Formula |
C12H18O11 |
|
| Molecular Weight (MW) | 338.26 | |
| SMILES | C(C1C(C(C(C(O1)OC2=C(C(OC2=O)C(CO)O)O)O)O)O)O |
Biological Activity
2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is a stable glucoside derivative of ascorbic acid that functions as a vitamin C prodrug. Enzymatic hydrolysis by α-glucosidase slowly releases active ascorbic acid, which stimulates cellular collagen synthesis and induces intracellular reactive oxygen species (ROS) generation. Downstream ROS accumulation leads to oxidative stress and cytotoxicity, thereby exerting antitumor activity against targeted cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(201.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 68 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Solubility in DMSO
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Stock Solution
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Storage
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Stability
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Molecular Weight
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid SMILES
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid Chemical Structure (2D and 3D)
- 2-O-α-D-Glucopyranosyl-L-ascorbic acid SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.